Recent Articles

Lecca S, Meye FJ, Trusel M, Tchenio A, Harris J, Schwarz MK, Burdakov D, Georges F & Mameli M. Aversive stimuli drive hypothalamus to habenula excitation to promote escape behavior. eLife. 2017. Epub online.

Valentinova K. and Mameli M.. Cocaine, cadherins and synaptic plasticity. Nat Neurosci. 2017 Mar 29;20(4):499-501.

Lecca S., Trusel M., Mameli M.. Footshock-induced plasticity of GABAB signalling in the lateral habenula requires dopamine and glucocorticoid receptors. Synapse. 2016 Nov 10. doi: 10.1002/syn.21948.

Valentinova K., and Mameli M. mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output. Cell Rep. 2016 August.

Meye FJ, Soiza-Reilly M, Smit T, Diana MA, Schwarz  MK & Mameli M. Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse. Nat Neurosci. 2016 Jun 27. doi: 10.1038/nn.4334

Lecca S., Pelosi A., Tchenio A., Moutkine I., Lujan R., Herve’ D. and Mameli M.. Rescue of GABAB and GIRK function in the lateral habenula by protein phosphatase 2A inhibition ameliorates depression-like phenotypes in mice. Nat Medicine 2016 Jan 25. doi: 10.1038/nm.4037.

Glangetas C, Fois GR, Jalabert M, Lecca S, Valentinova K, Meye FJ, Diana M, Faure P, Mameli M, Caille S, Georges F.. Ventral Subiculum Stimulation Promotes Persistent Hyperactivity of Dopamine Neurons and Facilitates Behavioral Effects of Cocaine. Cell Rep. 2015 Dec 15;13(10):2287-96. doi: 10.1016/j.celrep.2015.10.076. Epub 2015 Nov 25.

Sakae DY*, Marti F*, Lecca S*, Vorspan F, Martín-García E, Morel LJ, Henrion A, GutiérrezCuesta J, Besnard A, Heck N, Herzog E, Bolte S, Prado V, Prado M, Bellivier F, Eap CB, Crettol S, Vanhoutte P, Caboche J, Gratton J , Giros B, Maldonado R, Daumas S, Mameli M, Jamain S, El Mestikawy S. The absence of VGLUT3 predisposes to cocaine abuse by increasing dopamine and glutamate signaling in the nucleus accumbens. Mol Psychiatry. 2015 Aug 4. doi: 10.1038/mp.2015.104.

Valentinova K, Tchenio A, Meye FJ, Lecca S, Mameli M. Hell after the pleasure: drug-induced negative symptoms involve lateral habenula. Med Sci (Paris). 2015 May;31(5):478-81. doi: 10.1051/medsci/20153105006.

Doly S, Shirvani H, Gäta G, Meye FJ, Emerit M-B, Enslen H, Achour L, Pardo-Lopez L, Yang S-K, Armand V, Gardette R, Giros B, Gassmann M, Bettler B, Mameli M, Darmon M and Marullo S. GABAB receptor cell-surface export is controlled by an endoplasmic reticulum gatekeeper. Mol Psychiatry AOP, June 2, 2015; doi:10.1038/mp.2015.72

Meye FJ*, Valentinova K*, Lecca S*, Marion-Poll L, Maroteaux MJ, Musardo S, Moutkine I, Gardoni F, Huganir RL, Georges F, Mameli M. Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula. Nat Neurosci. 2015 Feb 2. doi: 10.1038/nn.3923.

Yuan T, Mameli M, O’ Connor EC, Dey PN, Verpelli C, Sala C, Perez-Otano I, Lüscher C, Bellone C. Expression of cocaine-evoked synaptic plasticity by GluN3A-containing NMDA receptors. Neuron 2013 Nov 20;80(4):1025-38.

Stacey et al., RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. PNAS 2012 109 (51) 21128-21133.

Maroteaux M., Mameli M.. Cocaine-evokes projection-specific synaptic plasticity in the lateral habenula. JNeurosci. 2012 5;32(36):12641-6.

Bellone C., Mameli M., Lüscher C. In utero exposure to cocaine delays postnatal synaptic maturation of glutamatergic transmission in the VTA. Nat Neurosci. 2011; EPub 2011 Oct 2.

Mameli M., Bellone C., Brown T.C., Lüscher C. Cocaine inverts rules for synaptic plasticity of glutamate transmission in the VTA. Nat Neurosci. 2011 Apr;14(4):414-6. Epub 2011 Feb 20.

Brown T.C., Mameli M., Bellone C., Balland B., Dahan L., Lujan R., Deisseroth K., Lüscher C. Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. PLoS One. 2010 Dec 31;5(12):e15870.

Mameli M., Halbout B., Creton C., Engblom D., Parkitna J. R., Spanagel R., Lüscher C.. Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nat Neurosci. 2009 Aug;12(8):1036-41. Epub 2009 Jul 13.

Recent Reviews
Tchenio A, Valentinova K, Mameli M. Can the Lateral Habenula Crack the Serotonin Code?
Front Synaptic Neurosci. 2016 Oct 24;8:34.

Lecca S, Meye FJ, Mameli M. The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview. Eur J Neurosci. 2014 Apr;39(7):1170-8.

Meye F.J.M., Lecca S., Valentinova K and Mameli M.. Synaptic and cellular profile of neurons in the lateral habenula. Front Hum Neurosci. 2013 Dec 16;7:860.

Bellone C., and Mameli M.. mGluR-dependent synaptic plasticity in drug-seeking. Frontiers in Neuropharm. 2012.

Maroteaux M. and Mameli M. Synaptic Switch and Social Status. Science. 2011 Nov 4;334(6056):608-9.